An Overview of Regenerating Orthopedic Tissue

Dr. Farshchian has served as the medical director at Miami, Florida’s Center for Regenerative Medicine for nearly 15 years. In this position Dr. Farshchian excels in all areas of orthopedic regenerative medicine.

Orthopedic injuries can result in long-term, if not permanent, damage to cartilage, intra-articular ligaments, and the meniscus. Sometimes even bone matter can fail to properly mend after serious orthopedic trauma. Medical professionals seeking to encourage regeneration of orthopedic tissue will focus on four important areas. At the cellular level, differentiated cells from the injured tissue can be used to help with tissue growth, though mesenchymal stem cells are also a major resource. There is some debate about the importance of the source of origin of cells used for regeneration; both embryonic and induced pluripotent stem cells show potential.

Critical to the regeneration of orthopedic tissue are morphogenetic signals. Generally, these signals originate from individual recombinant growth factors, if not native, platelet-rich plasma mixtures. A number of additional mixtures can be used to further stimulate morphogenetic signals. Smart scaffolds are also instrumental in sustaining effective, ongoing growth factors. Finally, mechanical practices to support regeneration deal with in vivo intrinsic biological processes.